Figure out how to make 10 buttons, two analog sticks and a digital 4-way crossbar into a serviceable interface? Yes please! I'm that masochist. Off the top of my head:
Left stick for movement, right stick for camera, left and right upper triggers for tab targeting, lower left trigger for the new empower spell mechanic, lower right trigger as a modifier button, and the other 8 buttons (4 buttons + 4-way directional pad) provide 16 options for various spells and abilities. Masochistic players will map the lower left trigger to a second modifier, to bring the number of available abilities to 32 instead of using what inevitably will be something like an instant 8-way on-screen menu when hitting a button.
And since we're on a fast path to crazy town, consider this: once Blizzard develops a halfway decent controller scheme, they resolve the major non-technical hurdle standing in the way of bringing WoW to VR.