Depends if I'm playing a caster or melee. If caster, I bind instant abilities to my mouse with modifiers if needed. That way I can strafe/kite/be more mobile. Hard casted abilities are then bound to keyboard buttons.
For melee it's the kind of the opposite. I bind main abilities to the keyboard so I can mongo with my mouse and stay on my target more easily.
I use default, and use strafe very often, and move forward with the mouse very often, when my mouse broke I didn’t know wtf I was doing using wasd lmao