1. Look at the bosses loot table
2. Make a group of 4 49s that can loot the least amount of items from that table (although obv including the item you want)
3. Specific queue for what you need and truck through it. The % chance of your item dropping is drastically higher than on legacy loot mode and you have 3 other ppl in party at least who can loot the item and give it to you (after they get it)