Nope, the only issue you might encounter is using the modifier keys (CTRL, shift, alt), but you can work around it I guess. I would recommend adding 23456 to your keybinds since you are just moved over to the right from what most people use.
Then it shouldn't be a problem. For the most part, keybinding is all personal preference. You shouldn't worry to much about how you do it compared to others because hey, at least you aren't clicking. If anything, you can change your binds later it doesn't take that long to re learn them.