I always and only do Stonetalon Mountains for my farm route.
The best way to handle it is choose a route you like, and stick to it every day (or every three depending on the chest) for the foreseeable future.
When you first start, most will be down for the times you run, because they aren't set to that schedule, and random people will run by and open them. So don't get concerned if you are running the route, and you only get 1 chest. Most of the time, even if you are on a schedule, one run will only mean 2-5, thats just the way it goes.